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Many times, during the course of a pharmaceutical clinical study, expiration dating and the extension of clinical product beyond the original date becomes a critical need for sponsors. Ongoing stability trials may not be at a specific point in time such that real-time data is available to make an informed decision as to whether the product is still viable and whether the product expiration can be extended to maintain product in the clinics.
Through statistical analysis based upon both first-order kinetics and the use of the Arrhenius Equation, Sharp Clinical Services SCS can offer this rationale to clients in an effort to provide scientific reasoning that can reasonably extend the expiry of the product. The focus of this paper is to describe methods which provide this scientific rationale to evaluate and potentially extend expiry.
Puzzles Do you like puzzles? Specifically, mathematical puzzles. Within the pharmaceutical development cycle of drug products, expiry dating and even more so extensions of expiry are very complex mathematical puzzles. This paper hopes to shed some light on how to better connect the dots to provide sound reasoning in solving these complex puzzles. Stability and Expiry — A Complex Puzzle Going back to my original puzzle above in which three 3 is to twelve 12 as six 6 is to twenty-four 24 , puzzles are nothing more than an effort to find some solid connection between what appear to be separate and distinct pieces.
Find the connection, solve the puzzle. Imagine that piece Ravensburger puzzle in which you try to find the connections, which might be sorting the pieces into shapes, series of similar colors, looking at the picture on the cover or just plain sitting there trying to fit one into another. In the first puzzle above, the connection seems obvious that the answer is just a multiple of the first value.
THE BRAIN CHASE BLOG
Akilah J. Read on for the dating advice that she gives to her clients that are looking to meet someone. However, the type of dating perspective we take can help guide us through the dating process to ensure we form the relationships we desire. Envision a piece of playdough and a square block.
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In this video game image released by Atlus , a scene is shown from “Catherine. Catherine mixes a sort of dating simulation and a puzzle game with a splash of survival horror. It doesn’t fully succeed, but it’s completely original. You control Vincent, a slacker who’s muddling through a relationship with his longtime girlfriend, Katherine with a K. She’s beautiful, smart and ambitious, but she’s getting a little impatient waiting for Vincent to grow up.
Along comes Catherine with a C , a girly-girl who’s wearing little more than lingerie when she wanders into the bar where Vincent and his friends hang out. Vincent and Catherine end up in bed together, and the drama unfolds from there. Will Vincent confess his infidelity? Will he tell Katherine to beat it? And what’s the story behind an epidemic of young men dying in their sleep?
That’s where the puzzles come in. Every night, Vincent has a dream in which he’s forced to climb a towering wall while being pursued by a monster from his subconscious: a furious Katherine, perhaps, or a ravenous, caterwauling baby. The objective is to keep moving up, so you have to pull bricks from the wall to create staircases that Vincent can climb.
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In front of you are three doors. Behind each door is a prospective partner. Your mission is to couple up with your best possible match. Imagine you chose a door at random. If you couple up with the person behind it, the chance you get your best match is 1 in 3. You can assume that of the three people who are waiting behind the doors, there is a best match, a not so good match, and a least good match for you.
Cougar Lion Jigsaw Puzzle | Find this Pin and more on Lion, Tiger & Other Big Cat Themed Jigsaw Puzzles by AponxDiscoveries. Tags. Dating Tips.
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Unfreeze the game and let us play the girls. Game has had the girls frozen for 3 weeks. The grind is real on this game.